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. 2006 May;50(5):1893-5.
doi: 10.1128/AAC.50.5.1893-1895.2006.

Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic

Christian Dokomajilar  1 , Samuel L Nsobya, Bryan Greenhouse, Philip J Rosenthal, Grant Dorsey
Affiliations

Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic

Christian Dokomajilar et al. Antimicrob Agents Chemother. 2006 May.

Abstract

Polymorphisms in the Plasmodium falciparum pfmdr1 gene were assayed in pretreatment samples and in samples from patients reinfected following therapy with artemether-lumefantrine. The pfmdr1 alleles 86N, 184F, and 1246D significantly increased in prevalence after treatment. All samples had a single pfmdr1 copy. Treatment with artemether-lumefantrine selects for polymorphisms that may alter antimalarial drug response.

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Figures

FIG. 1.
FIG. 1.
Prevalence of pfmdr1 alleles in pretreatment samples and samples from newly infected patients following therapy with artemether-lumefantrine. Alleles typically classified as wild type are on the left, mixed infections are in the middle, and those classified as mutant are on the right.
See this image and copyright information in PMC

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