Synthesis of cancer-associated glycoantigens: stage-specific embryonic antigen 3 (SSEA-3)
- PMID: 16643871
- DOI: 10.1016/j.carres.2006.03.041
Synthesis of cancer-associated glycoantigens: stage-specific embryonic antigen 3 (SSEA-3)
Abstract
The synthesis of the tumor-associated carbohydrate antigens SSEA-3 and Gb3 in a semi-convergent fashion using building blocks bearing a S-thiazolinyl (STaz) moiety is reported. Complete stereoselective control of a difficult alpha-(1-->4)-galactosylation and high overall yields were achieved.
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