Does alpha+-thalassaemia protect against malaria?

Affiliations

Comment

Geoffrey Pasvol. PLoS Med. 2006 May.

. 2006 May;3(5):e235.

doi: 10.1371/journal.pmed.0030235. Epub 2006 May 9.

¹ Wellcome Centre for Clinical Tropical Medicine, Imperial College London, London, United Kingdom. g.pasvol@imperial.ac.uk

Abstract

Pasvol discusses a new study in PLoS Medicine that shows that α ⁺-thalassemia protects against severe but not mild malaria.

Competing Interests: The author has declared that no competing interests exist.

The effect of alpha+-thalassaemia on the incidence of malaria and other diseases in children living on the coast of Kenya.
Wambua S, Mwangi TW, Kortok M, Uyoga SM, Macharia AW, Mwacharo JK, Weatherall DJ, Snow RW, Marsh K, Williams TN. Wambua S, et al. PLoS Med. 2006 May;3(5):e158. doi: 10.1371/journal.pmed.0030158. Epub 2006 Apr 18. PLoS Med. 2006. PMID: 16605300 Free PMC article.

1. Haldane J. The rate of mutation of human genes. Proceedings of the Eighth International Congress of Genetics. Hereditas. 1949;35(Suppl):267–273.
1. Hill AV, Allsopp CE, Kwiatkowski D, Anstey NM, Twumasi P, et al. Common west African HLA antigens are associated with protection from severe malaria. Nature. 1991;352:595–600. - PubMed
1. Willcox M, Bjorkman A, Brohult J. Falciparum malaria and beta-thalassaemia trait in northern Liberia. Ann Trop Med Parasitol. 1983;77:335–347. - PubMed
1. Luzzi GA, Torii M, Aikawa M, Pasvol G. Unrestricted growth of Plasmodium falciparum in microcytic erythrocytes in iron deficiency and thalassaemia . Br J Haematol. 1990;74:519–524. - PubMed
1. Luzzi GA, Pasvol G. Cytoadherence of Plasmodium falciparum-infected alpha-thalassaemic red cells . Ann Trop Med Parasitol. 1990;84:413–414. - PubMed