The effect of dendritic cells activated by OK-432 and pulsed with antigens on cytokine induced killers
- PMID: 16647239
- DOI: 10.1016/j.biopha.2006.03.001
The effect of dendritic cells activated by OK-432 and pulsed with antigens on cytokine induced killers
Abstract
Aim: To study the effect of OK-432 on the maturation and function of human peripheral blood monocyte-derived dendritic cells, and the effect of these dendritic cells on the proliferation and anti-tumor function of cytokine induced killers.
Methods: Through the analysis of DCs' surface molecules, the detection of the proliferation and anti-tumor function of CIKs activated by DCs, we researched the influence of OK-432 on DCs and CIKs.
Results: OK-432 have the potential of promoting DCs to express CD1a, CD80, CD83, HLA-DR highly, which is stronger than LPS; DCs activated by OK-432 can facilitate the proliferation and function of CIKs.
Conclusion: OK-432 can induce DCs' maturation and can thus promote CIKs' functions.
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