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. 2006 May;60(4):156-60.
doi: 10.1016/j.biopha.2006.03.001. Epub 2006 Mar 31.

The effect of dendritic cells activated by OK-432 and pulsed with antigens on cytokine induced killers

Yong-Qian Shu  1 , Yanhong Gu
Affiliations

The effect of dendritic cells activated by OK-432 and pulsed with antigens on cytokine induced killers

Yong-Qian Shu et al. Biomed Pharmacother. 2006 May.

Abstract

Aim: To study the effect of OK-432 on the maturation and function of human peripheral blood monocyte-derived dendritic cells, and the effect of these dendritic cells on the proliferation and anti-tumor function of cytokine induced killers.

Methods: Through the analysis of DCs' surface molecules, the detection of the proliferation and anti-tumor function of CIKs activated by DCs, we researched the influence of OK-432 on DCs and CIKs.

Results: OK-432 have the potential of promoting DCs to express CD1a, CD80, CD83, HLA-DR highly, which is stronger than LPS; DCs activated by OK-432 can facilitate the proliferation and function of CIKs.

Conclusion: OK-432 can induce DCs' maturation and can thus promote CIKs' functions.

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