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Randomized Controlled Trial
. 2006 Apr;148(4):501-7.
doi: 10.1016/j.jpeds.2005.11.043.

A randomized clinical trial of dietary calcium to improve bone accretion in children with juvenile rheumatoid arthritis

Lori J Stark  1 , Ann McGrath Davis, David M Janicke, Laura M Mackner, Kevin A Hommel, Judy A Bean, Daniel Lovell, James E Heubi, Heidi J Kalkwarf
Affiliations
Randomized Controlled Trial

A randomized clinical trial of dietary calcium to improve bone accretion in children with juvenile rheumatoid arthritis

Lori J Stark et al. J Pediatr. 2006 Apr.

Abstract

Objective: To examine a behavioral intervention (BI) to increase calcium intake in children with juvenile rheumatoid arthritis (JRA) on calcium intake and bone mass 6 and 12 months after treatment.

Study design: A randomized trial compared a 6-session BI to a 3-session enhanced standard of care (ESC) with 49 children ages 4 to 10 years with JRA. Calcium intake was assessed via 3-day diet diaries. Total body bone mineral content (BMC), arms and legs BMC, and lumbar spine bone mineral density were assessed by dual energy x-ray absorptiometry.

Results: BI maintained an average calcium intake of 1500 mg/d at 6- and 12-month follow-up. This was greater than their baseline level of 972 mg/d, but not greater than the intake of 1300 mg/day maintained by ESC (P=.09). The BI had a 4% and 2.9% greater gain in total body bone mineral content than ESC at 6 and 12 months, respectively (P=.005), and a 7.1% and 5.3% greater gain in arms and legs BMC at 6 and 12 months than ESC (P=.0007).

Conclusions: BI is effective in increasing calcium intake and BMC in children with JRA over a 12-month period.

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