Effects of escitalopram on ethanol withdrawal syndrome in rats
- PMID: 16650516
- DOI: 10.1016/j.pnpbp.2006.03.028
Effects of escitalopram on ethanol withdrawal syndrome in rats
Abstract
The present study was designed to investigate the effects of escitalopram, a selective serotonin reuptake inhibitor, on ethanol withdrawal syndrome in rats. Adult male Wistar rats (266-278 g) were subjects. Ethanol (7.2%, v/v) was given to rats by a liquid diet for 21 days. Control rats were pair fed with an isocaloric liquid diet containing sucrose as a caloric substitute to ethanol. Escitalopram (2.5, 5 and 10 mg/kg) and saline were injected to rats intraperitoneally just before ethanol withdrawal. After the second and sixth hours of ethanol withdrawal, rats were observed for 5 min, and withdrawal signs that included locomotor hyperactivity, agitation, stereotyped behavior, wet dog shakes, tremors and audiogenic seizures were recorded or rated. A second series of injections was given 30 min before sixth hour of withdrawal test. Effects of escitalopram on the locomotor activities of the naïve (no ethanol-dependent) rats were also evaluated. Escitalopram (5 mg/kg) reduced the increased stereotyped behaviors at the sixth hour of ethanol withdrawal. It inhibited tremors at the second hour of ethanol withdrawal at doses of 5 and 10 mg/kg. Escitalopram (2.5 and 5 mg/kg) also produced some significant attenuations in the incidence of wet dog shakes at the second and sixth hours of the observation period. It was found ineffective on locomotor hyperactivity, agitation and audiogenic seizures. Escitalopram (2.5 and 5 mg/kg) did not cause any significant effect on locomotor activities of the naïve rats. Our results suggest that acute escitalopram treatment has some limited beneficial effects on ethanol withdrawal syndrome in rats.
Similar articles
-
Effects of clozapine on ethanol withdrawal syndrome in rats.Alcohol Alcohol. 2008 Nov-Dec;43(6):619-25. doi: 10.1093/alcalc/agn052. Epub 2008 Jun 25. Alcohol Alcohol. 2008. PMID: 18579515
-
Acute and chronic tianeptine treatments attenuate ethanol withdrawal syndrome in rats.Prog Neuropsychopharmacol Biol Psychiatry. 2006 May;30(3):478-85. doi: 10.1016/j.pnpbp.2005.11.013. Epub 2006 Jan 10. Prog Neuropsychopharmacol Biol Psychiatry. 2006. PMID: 16412550
-
Serotonergic anti-depressants and ethanol withdrawal syndrome: a review.Alcohol Alcohol. 2008 Jan-Feb;43(1):15-24. doi: 10.1093/alcalc/agm145. Epub 2007 Oct 12. Alcohol Alcohol. 2008. PMID: 17934195 Review.
-
Attenuation of ethanol withdrawal syndrome by extract of Hypericum perforatum in Wistar rats.Fundam Clin Pharmacol. 2006 Oct;20(5):481-8. doi: 10.1111/j.1472-8206.2006.00432.x. Fundam Clin Pharmacol. 2006. PMID: 16968419
-
Atypical antipsychotic drugs and ethanol withdrawal syndrome: a review.Alcohol Alcohol. 2012 Jan-Feb;47(1):33-41. doi: 10.1093/alcalc/agr142. Epub 2011 Oct 21. Alcohol Alcohol. 2012. PMID: 22021556 Review.
Cited by
-
Role of Standardized Plant Extracts in Controlling Alcohol Withdrawal Syndrome-An Experimental Study.Brain Sci. 2021 Jul 12;11(7):919. doi: 10.3390/brainsci11070919. Brain Sci. 2021. PMID: 34356153 Free PMC article.
-
Serotonergic Systems in the Pathophysiology of Ethanol Dependence: Relevance to Clinical Alcoholism.ACS Chem Neurosci. 2015 Jul 15;6(7):1026-39. doi: 10.1021/cn5003573. Epub 2015 Feb 19. ACS Chem Neurosci. 2015. PMID: 25654315 Free PMC article. Review.
-
Combined Effects of Acamprosate and Escitalopram on Ethanol Consumption in Mice.Alcohol Clin Exp Res. 2016 Jul;40(7):1531-9. doi: 10.1111/acer.13099. Epub 2016 May 17. Alcohol Clin Exp Res. 2016. PMID: 27184383 Free PMC article.
-
Commentary: Targeting NMDA Receptor and Serotonin Transporter for the Treatment of Comorbid Alcohol Dependence and Depression.Alcohol Clin Exp Res. 2017 Feb;41(2):275-278. doi: 10.1111/acer.13310. Epub 2017 Jan 19. Alcohol Clin Exp Res. 2017. PMID: 28102547 Free PMC article.
-
Role of the serotonergic system in alcohol dependence: from animal models to clinics.Prog Mol Biol Transl Sci. 2011;98:401-43. doi: 10.1016/B978-0-12-385506-0.00010-7. Prog Mol Biol Transl Sci. 2011. PMID: 21199778 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical