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Review
. 2006 May 1;66(9):4549-52.
doi: 10.1158/0008-5472.CAN-05-3850.

Exploring a new twist on tumor metastasis

Jing Yang  1 , Sendurai A Mani, Robert A Weinberg
Affiliations
Review

Exploring a new twist on tumor metastasis

Jing Yang et al. Cancer Res. .

Abstract

Unraveling the genetic programs that drive -metastasis may offer insights into how to limit or prevent this deadly aspect of cancer progression. Our recent studies indicate that tumor cell metastasis involves the activity of the transcription factor, Twist, which regulates epithelial-mesenchymal transition and early embryonic morphogenesis. Here, we review the Twist signaling pathway during normal development and discuss how the transcription factor Twist and the epithelial-mesenchymal transition program impinge their biological functions during tumor metastasis.

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Comment in

  • Models for spontaneous metastasis.
    Fidler IJ. Fidler IJ. Cancer Res. 2006 Oct 1;66(19):9787. doi: 10.1158/0008-5472.CAN-06-2396. Cancer Res. 2006. PMID: 17018641 No abstract available.

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