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Clinical Trial
. 1991;117 Suppl 4(Suppl 4):S139-40.
doi: 10.1007/BF01613219.

A randomised study of intravenous bolus versus continuous infusion of ifosfamide and doxorubicin with oral etoposide for small-cell lung cancer

H Anderson  1 , J Prendiville, N Thatcher, J A Radford, R Swindell
Affiliations
Clinical Trial

A randomised study of intravenous bolus versus continuous infusion of ifosfamide and doxorubicin with oral etoposide for small-cell lung cancer

H Anderson et al. J Cancer Res Clin Oncol. 1991.

Abstract

159 "poor risk" patients with previously untreated small cell lung cancer were entered into a randomised study of intravenous bolus versus continuous infusion chemotherapy with doxorubicin on weeks 1, 3, 5 and ifosfamide with mesna on weeks 2, 4, 6. Oral etoposide was given on days 1-5, 15-19, and 29-33. There was no difference in response rate or survival. However, patients treated with continuous infusion therapy had significantly less haematological toxicity (P = 0.0007), and less nausea and vomiting (P = 0.03).

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