Excitatory amino acid receptors in the mammalian periphery

Abstract

Aspartate and glutamate occur ubiquitously in free and chemically bound forms and have been considered primarily as substances of metabolic relevance. This focus has changed with the more recent discovery of their specific role as excitatory synaptic transmitters in the mammalian CNS. Enthusiasm for this concept has overshadowed the possibility that glutamate and aspartate may also have specific, receptor-mediated functions in the periphery. In this review, Sándor Erdö summarizes the current knowledge of excitatory amino acid (EAA) receptors outside the CNS, through which EAAs may modulate various functions in peripheral organs and tissues.