[Anti-idiotypic antibodies to the herpes simplex type-1 virus neutralize the virus' infectious activity]
[Article in
Russian]
- PMID: 1665620
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[Anti-idiotypic antibodies to the herpes simplex type-1 virus neutralize the virus' infectious activity]
[Article in
Russian]
Vopr Virusol.
1991 Jul-Aug.
Abstract
Immunochemical study of blood sera from mice immunized with rabbit immunoglobulins (AT1) to herpes simplex virus type I (HSV-I) detected antiidiotypic antibodies AT2 in five of them (antiID). The affinity-purified antiID were shown to induce in syngeneic mice production of antibody (AT3) interacting with HSV-I antigen. In vitro, antiID (AT3) were shown to neutralize the virus activity. Analysis of the results suggests that the antiID imitate the antigenic properties of HSV-I and can induce specific immune response.
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