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. 1991 Oct;104(2):287-8.
doi: 10.1111/j.1476-5381.1991.tb12421.x.

The effects of lectins on the release of EDRF from rabbit aorta

J F Kleha  1 , P Devesly, A Johns
Affiliations

The effects of lectins on the release of EDRF from rabbit aorta

J F Kleha et al. Br J Pharmacol. 1991 Oct.

Abstract

The effects of the lectins, wheat germ agglutinin (WGA) and concanavalin A (Con A) on endothelium intact pre-contracted rabbit aorta were investigated. WGA (8.3 microM) produced endothelium-dependent relaxations, while Con A (4.3 microM) produced a partially endothelium-dependent relaxation. The endothelium-dependent relaxations to WGA were completely reversed by N-acetylglucosamine, haemoglobin and methylene blue and were partially reversed by NG-monomethyl-L-arginine (L-NMMA). It is suggested that WGA works as an agonist in releasing endothelium-derived relaxing factor (EDRF) from the endothelium of rabbit aorta by interacting with a glycosylated receptor on endothelial cells.

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