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. 1991 Oct;104(2):292-3.
doi: 10.1111/j.1476-5381.1991.tb12423.x.

Investigation into species variants in tachykinin NK1 receptors by use of the non-peptide antagonist, CP-96,345

I J Beresford  1 , P J Birch, R M Hagan, S J Ireland
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Investigation into species variants in tachykinin NK1 receptors by use of the non-peptide antagonist, CP-96,345

I J Beresford et al. Br J Pharmacol. 1991 Oct.

Abstract

The affinity of the non-peptide antagonist CP-96,345 for tachykinin NK1 receptors has been estimated in a range of species by use of both radioligand binding and functional assays. CP-96,345 was 30-120 fold less active at NK1 receptors in rat and mouse than in the other species examined, including man. These results demonstrate the existence of species variations in NK1 receptors.

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