Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Oct;104(2):292-3.
doi: 10.1111/j.1476-5381.1991.tb12423.x.

Investigation into species variants in tachykinin NK1 receptors by use of the non-peptide antagonist, CP-96,345

I J Beresford  1 , P J Birch, R M Hagan, S J Ireland
Affiliations

Investigation into species variants in tachykinin NK1 receptors by use of the non-peptide antagonist, CP-96,345

I J Beresford et al. Br J Pharmacol. 1991 Oct.

Abstract

The affinity of the non-peptide antagonist CP-96,345 for tachykinin NK1 receptors has been estimated in a range of species by use of both radioligand binding and functional assays. CP-96,345 was 30-120 fold less active at NK1 receptors in rat and mouse than in the other species examined, including man. These results demonstrate the existence of species variations in NK1 receptors.

PubMed Disclaimer

References

    1. Science. 1991 Jan 25;251(4992):435-7 - PubMed
    1. Eur J Pharmacol. 1991 May 17;197(2-3):237-8 - PubMed
    1. Eur J Pharmacol. 1984 Jan 27;97(3-4):161-70 - PubMed
    1. Annu Rev Neurosci. 1991;14:123-36 - PubMed
    1. Peptides. 1986 Sep-Oct;7(5):855-64 - PubMed

LinkOut - more resources