Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Mar;7(3):289-93.
doi: 10.1128/AAC.7.3.289.

Phosphonoacetic acid-resistant herpes simplex virus infection in hairless mice

R J Klein, A E Friedman-Kien

Phosphonoacetic acid-resistant herpes simplex virus infection in hairless mice

R J Klein et al. Antimicrob Agents Chemother. 1975 Mar.

Abstract

Phosphonoacetic acid (PAA)-resistant type 1 herpes simplex virus population was isolated by repeated passage of the virus in the presence of this inhibitor. Hairless mice infected percutaneously with the inhibitor-resistant or the parental inhibitor-susceptible virus were treated intraperitoneally with PAA and 9-beta-d-arabinofuranosyl-adenine by using several different dosage schedules. Whereas 9-beta-d-arabinofuranosyl-adenine was effective both in the PAA-susceptible and PAA-resistant herpes simplex virus-induced skin infection, PAA suppressed only the infection induced by the parental PAA-susceptible virus.

PubMed Disclaimer

References

    1. Proc Soc Exp Biol Med. 1964 Jan;115:69-77 - PubMed
    1. Ann N Y Acad Sci. 1965 Jul 30;130(1):343-54 - PubMed
    1. Med J Aust. 1968 Jul 13;2(2):59-63 - PubMed
    1. Chemotherapy. 1968;13(6):321-38 - PubMed
    1. Am J Ophthalmol. 1972 Jul;74(1):81-8 - PubMed

Publication types

LinkOut - more resources