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. 1986 Dec;82(4):1036-9.
doi: 10.1104/pp.82.4.1036.

A New Lectin from Meadow Saffron (Colchicum automnale)

W J Peumans  1 , A K Allen, B P Cammue
Affiliations

A New Lectin from Meadow Saffron (Colchicum automnale)

W J Peumans et al. Plant Physiol. 1986 Dec.

Abstract

A lectin has been isolated from tubers of the meadow saffron (Colchicum autumnale). It is an octameric protein (M(r) 100,000) composed of 4A- and 4B-subunits of M(r) 15,000 and 10,000, respectively. It is a glycoprotein with 4.4% carbohydrate, the main sugars are (N-acetyl-) glucosamine, mannose, fucose, and xylose. Although the Colchicum autumnale agglutinin (CAA) agglutinates human red blood cells, it has a much higher activity with rabbit erythrocytes. With respect to its carbohydrate-binding specificity CAA behaves rather unusually as it is inhibited by lactose, galactose, N-acetylgalactosamine and related sugars when assayed with human red blood cells but not in assays with rabbit erythrocytes.

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