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Case Reports
. 2006 May;51(5):952-5.
doi: 10.1007/s10620-005-9009-9. Epub 2006 May 3.

Hepatocellular carcinoma occurring in a patient with Crohn's disease treated with both azathioprine and infliximab

Shawn C Chen  1 , Oscar W Cummings, Michael P Hartley, Carol A Filomena, Won Kyoo Cho
Affiliations
Case Reports

Hepatocellular carcinoma occurring in a patient with Crohn's disease treated with both azathioprine and infliximab

Shawn C Chen et al. Dig Dis Sci. 2006 May.

Abstract

Hepatocellular carcinoma is known to be associated with underlying liver diseases, such as cirrhosis, hemochromatosis, and chronic viral hepatitis. All reported cases of hepatocellular carcinoma in association with Crohn's disease involve patients treated previously with azathioprine or both azathioprine and steroids. However, hepatocellular carcinoma associated with the use of azathioprine and infliximab has not been reported. In this report, we describe an unusual case of hepatocellular carcinoma and focal hepatic glycogenosis (FHG) occurring in a non-cirrhotic Crohn's disease patient who has been treated with both azathioprine and infliximab.

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