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. 2006 Aug;12(8):505-8.
doi: 10.1002/psc.757.

Fluorescein-labeled stable neurotensin derivatives

Veronique Maes  1 , Christina Hultsch, Suzann Kohl, Ralf Bergmann, Thomas Hanke, Dirk Tourwé
Affiliations

Fluorescein-labeled stable neurotensin derivatives

Veronique Maes et al. J Pept Sci. 2006 Aug.

Abstract

Neurotensin(8-13) analogs containing a glycine or 5-aminovaleroyl spacer were labeled with fluorescein through formation of an N-terminal thiourea function. The receptor binding was measured in HT-29 cell cultures and showed a substantial decrease in affinity, especially for the metabolically stabilized [MeArg(9), Tle(11)] analog. Using fluorescence microscopy, the internalization of the fluorescent neurotensin analogs into HT-29 cells was observed.

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