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. 2006 May 3:4:24.
doi: 10.1186/1477-7819-4-24.

Thyroid papillary carcinoma arising in ectopic thyroid tissue within a neck branchial cyst

Angela Fumarola  1 , Pierpaolo Trimboli, Rossana Cavaliere, Iolanda Coletta, Alessandra Veltri, Agnese Di Fiore, Antonio Ciardi, Francesca Piccirilli
Affiliations

Thyroid papillary carcinoma arising in ectopic thyroid tissue within a neck branchial cyst

Angela Fumarola et al. World J Surg Oncol. .

Abstract

Background: Thyroid gland derives from one median anlage at the base of the tongue, and from the two fourth branchial pouches. A number of anomalies may occur during their migration. These can be in form of ectopic tissues, which are frequently found along the course of thyroglossal duct and rarely in other sites, many of these may develop same diseases as the thyroid gland.

Case presentation: A 36-years-old female presented with a 3 month history of left side neck mass. The mass disappeared following aspiration of brown colored fluid, which on cytological examination showed cells with nuclear irregularities that warranted the resection of the lesion. The histology demonstrated a thyroid papillary carcinoma arising within the branchial cyst. Thereafter, the patient underwent a total thyroidectomy with central lymph nodes dissection. Histology showed a multifocal papillary carcinoma with central lymph nodes metastases. Only four cases of primary thyroid carcinomas in neck branchial cyst have been described so far.

Conclusion: In a lateral cystic neck mass, although rare, occurrence of ectopic thyroid tissue and presence of a papillary thyroid carcinoma should be kept in mind.

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Figures

Figure 1
Figure 1
Neck ultrasound evaluation showed a mixed solid and cystic lesion with septations, and irregular and thick margins in lateral region.
Figure 2
Figure 2
Computed tomography showing a low density lesion with irregular and thick margins in lateral neck region.
Figure 3
Figure 3
Photomicrograph show the thick wall of the cyst with adiacent area of papillary carcinoma (follicular variant) (HE 50×), with the nuclear features of the lesion (inset, HE, 400×).
Figure 4
Figure 4
Section of the cyst wall showing the lining composed of cuboidal cells with positive staining for thyroglobulin at the apical portion of cytoplasm. (DAB, 250×).
See this image and copyright information in PMC

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