Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 May 24;538(1-3):39-42.
doi: 10.1016/j.ejphar.2006.02.053. Epub 2006 Mar 13.

The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family

Lucien C D Gibson  1 , Stuart F Hastings, Ian McPhee, Robert A Clayton, Claire E Darroch, Alison Mackenzie, Fiona L Mackenzie, Michiaki Nagasawa, Patricia A Stevens, Simon J Mackenzie
Affiliations

The inhibitory profile of Ibudilast against the human phosphodiesterase enzyme family

Lucien C D Gibson et al. Eur J Pharmacol. .

Abstract

Ibudilast is widely used in Japan to treat ischemic stroke and bronchial asthma. Its mode of action is through the inhibition of cyclic nucleotide phosphodiesterases (PDEs). Growing evidence suggests this compound has utility in a range of neurological conditions linked to its ability to elevate cellular cyclic nucleotide concentrations, however limited data exists on Ibudilast's action on individual PDE families. We therefore used an extensive panel of human PDE enzymes to define the PDE inhibitory profile of this compound. Ibudilast preferentially inhibits PDE3A, PDE4, PDE10 and PDE11 with lesser inhibition of a number of other families. The significance of these findings is discussed in relation to Ibudilast's observed effects on certain disease states.

PubMed Disclaimer

LinkOut - more resources