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Review
. 2006 Dec;15(6):718-27.
doi: 10.1016/j.breast.2006.02.005. Epub 2006 May 3.

Cyclin D1 and breast cancer

Pankaj G Roy  1 , Alastair M Thompson
Affiliations
Review

Cyclin D1 and breast cancer

Pankaj G Roy et al. Breast. 2006 Dec.

Abstract

Cyclin D1 is one of the frequently overexpressed proteins and one of the commonly amplified genes in breast cancer. This article reviews the roles of cyclin D1 in cell-cycle regulation (normal and abnormal), mammary gland development and carcinogenesis and the relationship to oestrogen in breast tissues. It concludes by presenting the clinical, prognostic and therapeutic implications of our current knowledge of cyclin D1 in breast cancer.

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