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Review
. 2006 May 1;12(9):2651-6.
doi: 10.1158/1078-0432.CCR-06-0497.

Advanced generation adenoviral virotherapy agents embody enhanced potency based upon CAR-independent tropism

J Michael Mathis  1 , Phoebe L Stewart, Zheng B Zhu, David T Curiel
Affiliations
Review

Advanced generation adenoviral virotherapy agents embody enhanced potency based upon CAR-independent tropism

J Michael Mathis et al. Clin Cancer Res. .
No abstract available

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Figures

Fig. 1
Fig. 1
Sschematic representation of the interaction of Ad37 with CD46 and αvβ5 integrin. A, cryoelectron microscopy reconstruction of the Ad37F vector with the full-length Ad37 fiber. A surface representation with fibers (green), penton bases (yellow), and the rest of the capsid (blue). B, a model of the interaction of an Ad37 fiber with CD46 (magenta) at the host cell membrane (orange). C, a model of the dual interaction of an Ad37 fiber with CD46 and penton base with αvβ5 integrin (red). Integrin is represented by cryoelectron microscopy density from theAd12/αvβ5 reconstruction (62). A, B,and C are modified from Chiu et al (43) and reprinted with permission from the American Society for Microbiology. Bar, 100 Å.
See this image and copyright information in PMC

Comment on

References

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