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Comparative Study
. 1991 Apr-Jun;23(2):86-9.

[Lysosomotropic compounds inhibiting the multiplication of Junin virus]

[Article in Spanish]
V Castilla  1 , S E Mersich, E B Damonte
Affiliations
  • PMID: 1667699
Comparative Study

[Lysosomotropic compounds inhibiting the multiplication of Junin virus]

[Article in Spanish]
V Castilla et al. Rev Argent Microbiol. 1991 Apr-Jun.

Abstract

A number of lysosomotropic compounds of diverse chemical structure, ammonium chloride, procaine and chlorpheniramine, were found to inhibit the infection of Vero cells by Junín virus. Viral replication was almost totally inhibited by 15 mM ammonium chloride, when added either before or within the first hour of infection and a significant inhibition (97.8%) was observed when it was added 8 hours after infection. These results agree with a model which postulates that arenavirus entry occurs by receptor-mediated endocytosis.

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