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Review
. 2006 Apr;8(5):1382-9.
doi: 10.1016/j.micinf.2005.12.016. Epub 2006 Mar 23.

The systemic inflammatory response syndrome

Charles M Robertson  1 , Craig M Coopersmith
Affiliations
Free article
Review

The systemic inflammatory response syndrome

Charles M Robertson et al. Microbes Infect. 2006 Apr.
Free article

Abstract

The systemic inflammatory response syndrome (SIRS) is the body's response to an infectious or noninfectious insult. Although the definition of SIRS refers to it as an "inflammatory" response, it actually has pro- and anti-inflammatory components. This review outlines the pathophysiology of SIRS and highlights potential targets for future therapeutic intervention in patients with this complex entity.

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