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Review
. 2006 Nov;59(11):1133-50.
doi: 10.1136/jcp.2005.031260. Epub 2006 May 5.

An approach to duodenal biopsies

S Serra  1 , P A Jani
Affiliations
Review

An approach to duodenal biopsies

S Serra et al. J Clin Pathol. 2006 Nov.

Abstract

The introduction of endoscopy of the upper digestive tract as a routine diagnostic procedure has increased the number of duodenal biopsy specimens. Consequently, the pathologist is often asked to evaluate them. In this review, a practical approach to the evaluation of a duodenal biopsy specimen is discussed. An overview of the handling of specimens is given and the normal histology and commonly encountered diseases are discussed. Finally, a description of commonly seen infections is provided, together with an algorithmic approach for diagnosis.

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Conflict of interest statement

Competing interests: None declared.

References

    1. Anon Normal embryology and fetal development. In: Morson and Dawson's gastrointestinal pathology. 4th edn. Blackwell Publishing 2003252–254.
    1. Kori M, Gladish V, Ziv‐Sokolovskaya N.et al The significance of routine duodenal biopsies in pediatric patients undergoing upper intestinal endoscopy. J Clin Gastroenterol 20033739–41. - PubMed
    1. Hopper A D, Cross S S, McAlindon M E.et al Symptomatic giardiasis without diarrhea: further evidence to support the routine duodenal biopsy? Gastrointest Endosc 200358120–122. - PubMed
    1. Shidrawi R G, Przemioslo R, Davies D R.et al Pitfalls in diagnosing coeliac disease. J Clin Pathol 199447693–694. - PMC - PubMed
    1. Ravelli A, Bolognini S, Gambarotti M.et al Variability of histologic lesions in relation to biopsy site in gluten‐sensitive enteropathy. Am J Gastroenterol 2005100177–185. - PubMed