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Review
. 2006 May;82(967):338-42.
doi: 10.1136/pgmj.2005.038273.

Clinical outcome of patients with Helicobacter pylori infection: the bug, the host, or the environment?

S N Sgouros  1 , C Bergele
Affiliations
Review

Clinical outcome of patients with Helicobacter pylori infection: the bug, the host, or the environment?

S N Sgouros et al. Postgrad Med J. 2006 May.

Abstract

It is well established that only a minority of patients with Helicobacter pylori infection develop severe inflammation leading to peptic ulcer or gastric cancer. Recent evidence suggests that the virulence factors of the organism do not seem crucial in the progression of inflammation towards a more severe disease. It seems probable that other host derived and environmental factors are more significant in determining clinical outcome but additional studies are needed to clarify the underlying mechanisms involved in the pathogenesis of infection.

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Conflict of interest statement

Competing interests: none declared.

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