Review
doi: 10.1159/000093178.
Epub 2006 May 4.
Accurate measurement and clinical significance of urinary transforming growth factor-beta1
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- PMID: 16679757
- DOI: 10.1159/000093178
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Review
Accurate measurement and clinical significance of urinary transforming growth factor-beta1
Am J Nephrol.
2006.
Abstract
Transforming growth factorbeta1 (TGF-beta1) is the main modulator of the healing process after tissue injury. In the kidney, if TGF-beta1 release is not switched off, extracellular matrix components (ECM) are accumulated and tissue fibrosis occurs. Urinary TGF-beta1 levels reflect its renal production and it has been determined in various types of glomerular disease. In this review, a critical analysis of the different immunoassays that have been used for the measurement of TGF-beta1 in the urine is presented and the importance of the serial determination of urinary TGF-beta1 levels in patients with various types of renal disease is discussed.
Copyright 2006 S. Karger AG, Basel
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