Comparative Study
[The action of an alkylating analog of hexadecamethonium on neuromuscular transmission in the frog]
[Article in
Russian]
- PMID: 1668154
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Comparative Study
[The action of an alkylating analog of hexadecamethonium on neuromuscular transmission in the frog]
[Article in
Russian]
Fiziol Zh SSSR Im I M Sechenova.
1991 Jul.
Abstract
The treatment of m. cutaneus pectoris-n. pectoralis preparations with 0.5 microM of alkylating derivate of hexadecamethonium, hexadecamethylene-bis-methylchloroethylamine, led to irreversible decrease of the amplitude of EPPs. The decrease was shown to be of a postsynaptic nature. After pretreatment of the neuromuscular preparations with alkylating derivate the effects of cholinesterase inhibitors were strongly diminished.
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