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Review
. 1991 Nov-Dec;7(11-12):403-8.
doi: 10.1016/0168-9525(91)90264-q.

Choosing a cell fate: a view from the Notch locus

S Artavanis-Tsakonas  1 , P Simpson
Affiliations
Review

Choosing a cell fate: a view from the Notch locus

S Artavanis-Tsakonas et al. Trends Genet. 1991 Nov-Dec.

Abstract

During the development of Drosophila melanogaster, individual cells must make choices between a restricted set of possible fates in order to give rise to spatial patterns composed of different types of differentiated cells. The Notch locus appears to play a central and general role in the regulative events that control the local architecture of the final cellular pattern in several tissues, among them being the central and peripheral nervous systems.

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