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Case Reports
. 2006 May;167(1):47-50.
doi: 10.1016/j.cancergencyto.2005.08.018.

Myelodysplastic syndromes with isolated deletion of the long arm of the chromosome X as a sole cytogenetic change

Yulia V Olshanskaya  1 , Alla I Udovichenko, Lubov A Vodinskaya, Eugenia N Glasko, Elena N Parovitchnikova, Yurii Yu Lorie, Valentina N Dvirnik, Valerii G Savchenko, Elena V Domracheva
Affiliations
Case Reports

Myelodysplastic syndromes with isolated deletion of the long arm of the chromosome X as a sole cytogenetic change

Yulia V Olshanskaya et al. Cancer Genet Cytogenet. 2006 May.

Abstract

Deletions of Xq are extremely rare events in myelodysplastic syndromes (MDS) patients and were previously described in five patients, in two of them as a sole chromosome abnormality. We found isolated del(Xq) in 3 of 127 MDS patients with clonal chromosome changes. Detailed analysis of clinical and morphological data of presented and previously published cases indicates the following: (1) del(X)(q24) and del(X)(q13) are nonrandom chromosomal abnormalities in MDS; (2) MDS with deletions of Xq affect exclusively females ages 46-65; and (3) deletions of Xq are associated with refractory anemia with excess blasts (RAEB) and indicate an unfavorable prognosis.

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