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Comment
. 2006 May 15;203(5):1143-5.
doi: 10.1084/jem.20060849. Epub 2006 May 8.

Telomerase flies the coop: the telomerase RNA component as a viral-encoded oncogene

Steven E Artandi  1
Affiliations
Comment

Telomerase flies the coop: the telomerase RNA component as a viral-encoded oncogene

Steven E Artandi. J Exp Med. .

Abstract

Telomerase, the enzyme that elongates our telomeres, is crucial for cancer development based on extensive analyses of human cells, human cancers, and mouse models. New data now suggest that a viral telomerase RNA gene encoded by Marek's disease virus (MDV), an oncogenic herpesvirus of chickens, promotes tumor formation. These findings highlight the importance of telomerase in cancer and raise new questions regarding the mechanisms by which the telomerase RNA component supports tumorigenesis.

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References

    1. O'Shea, C.C. 2005. DNA tumor viruses—the spies who lyse us. Curr. Opin. Genet. Dev. 15:18–26. - PubMed
    1. Boshoff, C., and Y. Chang. 2001. Kaposi's sarcoma-associated herpesvirus: a new DNA tumor virus. Annu. Rev. Med. 52:453–470. - PubMed
    1. Osterrieder, N., J.P. Kamil, D. Schumacher, B.K. Tischer, and S. Trapp. 2006. Marek's disease virus: from miasma to model. Nat. Rev. Microbiol. 4:283–294. - PubMed
    1. Fragnet, L., M.A. Blasco, W. Klapper, and D. Rasschaert. 2003. The RNA subunit of telomerase is encoded by Marek's disease virus. J. Virol. 77:5985–5996. - PMC - PubMed
    1. Blackburn, E.H. 2001. Switching and signaling at the telomere. Cell. 106:661–673. - PubMed

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