Review
doi: 10.1093/glycob/1.5.441.
Sialic acid activation
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- PMID: 1668304
- DOI: 10.1093/glycob/1.5.441
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Review
Sialic acid activation
Glycobiology.
1991 Nov.
Abstract
Cytidine 5'-monophosphosialic acid (CMP-sialic acid) is the activated form of sialic acid which is required for the biosynthesis of sialic acid-containing complex carbohydrates. Its discovery over 30 years ago by the laboratory of Dr Saul Roseman was a landmark in research dealing with the biosynthesis of these compounds. A review is presented of the salient features concerning this molecule: its discovery, chemistry, biosynthesis, subcellular location, enzymatic cleavage, transport and molecular biology. This report does not deal with its utilization by the sialyltransferases.
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