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. 2006 Sep;10(3):217-24.
doi: 10.1007/s00784-006-0049-0. Epub 2006 May 9.

Bone apposition to titanium implants biocoated with recombinant human bone morphogenetic protein-2 (rhBMP-2). A pilot study in dogs

Jürgen Becker  1 , Axel Kirsch, Frank Schwarz, Maria Chatzinikolaidou, Daniel Rothamel, Vojislav Lekovic, Markus Laub, Herbert Peter Jennissen
Affiliations

Bone apposition to titanium implants biocoated with recombinant human bone morphogenetic protein-2 (rhBMP-2). A pilot study in dogs

Jürgen Becker et al. Clin Oral Investig. 2006 Sep.

Erratum in

  • Clin Oral Investig. 2006 Sep;10(3):225. Laub, Markus [added]

Abstract

The aim of the present study was to investigate bone formation to recombinant human bone morphogenetic protein-2 (rhBMP-2)-biocoated and rhBMP-2-nonbiocoated titanium implants after implantation in dogs. Implantation of sand-blasted and acid-etched (C), chromosulfuric acid surface-enhanced (CSA), and rhBMP-2-biocoated CSA [BMP-A: noncovalently immobilized rhBMP-2 (596 ng/cm(2)), BMP-B: covalently immobilized rhBMP-2 (819 ng/cm(2))] implants was performed in both the mandible and tibia of dogs. After 4 weeks of healing, the percentage of direct bone to implant contact (BIC) and the induced bone density (BD) at a distance of less than and greater than 1 mm adjacent to each implant was assessed. Histomorphometric analysis of implants inserted in the mandible and tibia revealed that BIC values appeared to be highest in the BMP-B group, followed by BMP-A, CSA, and C. BD as measured at a distance of <1 mm revealed obvious differences between groups: BMP-B>BMP-A>CSA>C. However, no differences between groups were observed at a distance of >1 mm. Within the limits of the present study, it may be concluded that rhBMP-2 immobilized by covalent and noncovalent methods on CSA-treated implant surfaces seemed to be stable and promoted direct bone apposition in a concentration-dependent manner.

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Figures

Fig. 1
Fig. 1
Boxplots with outliners for the medians and Q1–Q3 quartiles of BIC and BD (%) in different groups after 4 weeks of healing with respective values in the crestal and apical portion of the implant (BIC) and at a distance of less than and greater than 1 mm adjacent to the implant surface (BD). Lines below and above box plots min, max. control c. a BIC mandibula. b BIC tibia. c BD tibia
Fig. 2
Fig. 2
Histology of representative titanium implants after 4 weeks of healing in the mandible (original magnification ×40). BIC appeared to be highest for BMP-B, followed by BMP-A, CSA, and C. a C. b CSA. c BMP-A. d BMP-B
Fig. 3
Fig. 3
Histology of representative titanium implants after 4 weeks of healing in the tibia (original magnification ×10). BIC and BD appeared to be highest for BMP-B, followed by BMP-A, CSA, and C. a C. b CSA. c BMP-A. d BMP-B
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