Gemcitabine-induced rectus abdominus radiation recall

Abstract

Context: Radiation recall has been described in the context of gemcitabine chemotherapy. However, this phenomenon has been largely limited to skin.

Case report: We hereby report a case of radiation recall dermatitis and myositis occurring on gemcitabine monotherapy, five months after completing chemoradiation for locally advanced pancreatic cancer. Radiation recall resolved spontaneously with withdrawal of gemcitabine.

Conclusions: This is the second case report that describes gemcitabine-induced radiation recall in rectus abdominus muscles after gemcitabine-based radiation therapy. Given the wide use of gemcitabine following chemoradiation for pancreatic cancer, providers should be aware of this potential complication.