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. 2006 Jun;78(6):1084-8; author reply 1092-4.
doi: 10.1086/504728.

Genomewide association, Parkinson disease, and PARK10

Matthew J Farrer, Kristoffer Haugarvoll, Owen A Ross, Jeremy T Stone, Nicole M Milkovic, Stephanie A Cobb, Andrew J Whittle, Sarah J Lincoln, Mary M Hulihan, Michael G Heckman, Linda R White, Jan O Aasly, J Mark Gibson, David Gosal, Timothy Lynch, Zbigniew K Wszolek, Ryan J Uitti, Mathias Toft

Genomewide association, Parkinson disease, and PARK10

Matthew J Farrer et al. Am J Hum Genet. 2006 Jun.
No abstract available

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Figures

Figure  1
Figure  1
Metric LD map and haplotype block structure of the investigated region. A, LD map providing information about LD patterns in the investigated candidate region, through locations expressed in LDUs. LDUs have an inverse relationship with LD, with regions of extensive recombination having many LDUs. The physical position of the gene in the region LOC200008 is marked with an arrow. All 28 SNPs genotyped are reported, although the symbols (▴) may be obscured for SNPs that lie in close physical proximity and high LD. SNPs rs682705 and rs7520966 are denoted by an asterisk (*). B, LD structure of the candidate region. Black and dark gray cells, strong LD; gray cells, intermediate; and light gray and white cells, evidence for historical recombination. The haplotype block structure of the region is defined according to Gabriel et al. An asterisk denotes SNPs rs682705 and rs7520966. The LD map and haplotype structure were constructed using genotypes from the Norwegian sample. Similar results were obtained for the Irish population.
See this image and copyright information in PMC

Comment in

References

Web Resources

    1. dbSNP, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=snp
    1. Online Mendelian Inheritance in Man (OMIM), http://www.ncbi.nlm.nih.gov/Omim/ (for PD, LRRK2, PARK10, and SEMA5A)

References

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    1. Maraganore DM, de Andrade M, Lesnick TG, Strain KJ, Farrer MJ, Rocca WA, Pant PVK, Frazer KA, Cox DR, Ballinger DG (2005) High-resolution whole-genome association study of Parkinson disease. Am J Hum Genet 77:685–693 - PMC - PubMed

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