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Review
. 2006 Jan 17;2006(318):er1.
doi: 10.1126/stke.3182006er1.

Regulation of voltage-gated Ca2+ channels by calmodulin

D Brent Halling  1 , Paula Aracena-Parks, Susan L Hamilton
Affiliations
Review

Regulation of voltage-gated Ca2+ channels by calmodulin

D Brent Halling et al. Sci STKE. .

Abstract

Calmodulin, a highly versatile and ubiquitously expressed Ca2+ sensor, regulates the function of many enzymes and ion channels. Both Ca2+-dependent inactivation and Ca2+-dependent facilitation of the voltage-gated Ca2+ channels Cav1.2 andCav2.1 are regulated through an interaction with Ca2+-bound calmodulin. This review addresses the functional regulation of Cav1.2 and Cav2.1 by calmodulin and discusses how Ca2+ binding to a single calmodulin molecule can regulate opposing functions of the voltage-gated Ca2+ channels.

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