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Case Reports
. 2006 May;27(5):1096-7.

Bisphosphonate-associated mandibular osteonecrosis

E Carneiro  1 , P Vibhute, A Montazem, P M Som
Affiliations
Case Reports

Bisphosphonate-associated mandibular osteonecrosis

E Carneiro et al. AJNR Am J Neuroradiol. 2006 May.

Abstract

A 66-year-old man with multiple myeloma treated with zoledronic acid, melphalan, and prednisone after a tooth extraction developed severe osteonecrosis of the mandible that was nonresponsive to antibiotic therapy. A CT scan showed innumerable fragmented sequestra in the mandible and some adjacent soft tissue fullness around the mandible. The association between the use of bisphosphonates and osteonecrosis of the jaw has been described only recently.

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Figures

Fig 1.
Fig 1.
Serial axial (A and B) and coronal (C–E) CT scans of the mandible show extensive fragmentation and sequestration of this edendulous mandible. There was mild adjacent soft tissue fullness. This degree of osteonecrosis would be excessive for the more common radiation-related disease.
See this image and copyright information in PMC

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