Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2006 Aug;26(8):476-80.
doi: 10.1038/sj.jp.7211530. Epub 2006 May 11.

Work of breathing using high-flow nasal cannula in preterm infants

J G Saslow  1 , Z H Aghai, T A Nakhla, J J Hart, R Lawrysh, G E Stahl, K H Pyon
Affiliations
Randomized Controlled Trial

Work of breathing using high-flow nasal cannula in preterm infants

J G Saslow et al. J Perinatol. 2006 Aug.

Abstract

Objective: To compare the work of breathing (WOB) in premature neonates supported with high-flow nasal cannula (HFNC) and nasal continuous positive airway pressure (NCPAP).

Study design: Eighteen preterm neonates <2.0 kg on HFNC or NCPAP support were studied in a random order. A ventilator was used to deliver 6 cm H2O of NCPAP with nasal prongs. High-flow nasal cannula delivered with Vapotherm (VAPO) at 3, 4 and 5 l/min was used. Tidal ventilation was obtained using respiratory inductance plethysmography calibrated with face-mask pneumotachography. An esophageal balloon estimated pleural pressure from which changes in end distending pressure were calculated. Inspiratory, elastic and resistive WOB and respiratory parameters were calculated.

Results: No differences were found in the WOB for all settings. Changes in end distending pressure did not vary significantly over all device settings except VAPO at 5 l/min.

Conclusion: In these preterm infants with mild respiratory illness, HFNC provided support comparable to NCPAP.

PubMed Disclaimer

Comment in

Publication types