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Comparative Study
. 2006 Apr;7(2):70-4.
doi: 10.1007/s10194-006-0281-7. Epub 2006 Apr 26.

The association between headache and Val158Met polymorphism in the catechol-O-methyltransferase gene: the HUNT Study

Knut Hagen  1 , Elin Pettersen, Lars Jacob Stovner, Frank Skorpen, John-Anker Zwart
Affiliations
Comparative Study

The association between headache and Val158Met polymorphism in the catechol-O-methyltransferase gene: the HUNT Study

Knut Hagen et al. J Headache Pain. 2006 Apr.

Abstract

The catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception, and one study has found that migraine was less likely among those with the Val/Val polymorphism. In the 1995-97 Nord-Trøndelag Health (HUNT) Study, the association between the Val158Met polymorphism and headache was evaluated in a random sample of 2451 individuals. No association between Val158Met polymorphism and migraine was found. Among women, a lower prevalence of non-migrainous headache was found among individuals with the Val/Val genotype than among those with other genotypes (26.2% vs. 33.6%, p = 0.04). That non-migrainous headache was less likely among women with the Val/Val genotype may be an incidental finding, but should be investigated in further studies.

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