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Comparative Study
. 2005 Nov;3(4):247-51.
doi: 10.1016/s1672-0229(05)03035-4.

Predicting the coupling specificity of GPCRs to G-proteins by support vector machines

Cui Ping Guan  1 , Zhen Ran Jiang, Yan Hong Zhou
Affiliations
Comparative Study

Predicting the coupling specificity of GPCRs to G-proteins by support vector machines

Cui Ping Guan et al. Genomics Proteomics Bioinformatics. 2005 Nov.

Abstract

G-protein coupled receptors (GPCRs) represent one of the most important classes of drug targets for pharmaceutical industry and play important roles in cellular signal transduction. Predicting the coupling specificity of GPCRs to G-proteins is vital for further understanding the mechanism of signal transduction and the function of the receptors within a cell, which can provide new clues for pharmaceutical research and development. In this study, the features of amino acid compositions and physiochemical properties of the full-length GPCR sequences have been analyzed and extracted. Based on these features, classifiers have been developed to predict the coupling specificity of GPCRs to G-proteins using support vector machines. The testing results show that this method could obtain better prediction accuracy.

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References

    1. LeVine H., 3rd Structural features of heterotrimeric G-protein-coupled receptors and their modulatory proteins. Mol. Neurobiol. 1999;19:111–149. - PubMed
    1. Elrod D.W., Chou K.C. A study on the correlation of G-protein-coupled receptor types with amino acid composition. Protein Eng. 2002;15:713–715. - PubMed
    1. Bockaert J., Pin J.P. Molecular tinkering of G protein-coupled receptors: an evolutionary success. EMBO J. 1999;18:1723–1729. - PMC - PubMed
    1. Moller S. Prediction of the coupling specificity of G protein coupled receptors to their G proteins. Bioinformatics. 2001;17:S174–S181. - PubMed
    1. Cao J. A naive Bayes model to predict coupling between seven transmembrane domain receptors and G-proteins. Bioinformatics. 2003;19:234–240. - PubMed

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