Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Feb;11(1):39-43.
doi: 10.1007/BF00422816.

The mechanism of alloxan toxicity: an indication for alloxan complexes in tissues and alloxan inhibition of 4-acetamido-4'-isothiocyanato-stilbene-2,2'-disulphonic acid (SITS) binding for the liver cell membrane

N Bilić

The mechanism of alloxan toxicity: an indication for alloxan complexes in tissues and alloxan inhibition of 4-acetamido-4'-isothiocyanato-stilbene-2,2'-disulphonic acid (SITS) binding for the liver cell membrane

N Bilić. Diabetologia. 1975 Feb.

Abstract

It is shown that alloxan inhibits binding of SITS to liver cells. This indicates the cell membrane as a site of alloxan action. Alloxan is found to react with tissues to form complexes that are detectable up to 3 hrs after alloxan treatment. On the basis of the present findings, an assumption is made that alloxan inhibits a cell membrane processes by blockade of functionally importnat groups.

PubMed Disclaimer

References

    1. Biochim Biophys Acta. 1967 Sep 9;135(4):580-90 - PubMed
    1. Biochem Pharmacol. 1970 Mar;19(3):687-95 - PubMed
    1. Am J Physiol. 1973 Mar;224(3):718-22 - PubMed
    1. Biochim Biophys Acta. 1971 Jul 6;241(1):147-54 - PubMed
    1. J Biol Chem. 1949 Jan;177(1):197-204 - PubMed