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Comment
. 2006 May 12;312(5775):848; author reply 848.
doi: 10.1126/science.1109904.

Comment on "Evidence for positive epistasis in HIV-1"

Kai Wang  1 , John E Mittler, Ram Samudrala
Affiliations
Comment

Comment on "Evidence for positive epistasis in HIV-1"

Kai Wang et al. Science. .

Abstract

Bonhoeffer et al. (Reports, 26 November 2004, p. 1547) presented evidence for positive epistasis in a clinical data set of HIV-1 mutants and corresponding fitness values. We demonstrate that biases in the original and simulated data sets may lead to erroneous evidence for epistasis. More rigorous statistical tests must be used to account for such biases before one can infer epistasis.

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Comment on

  • Evidence for positive epistasis in HIV-1.
    Bonhoeffer S, Chappey C, Parkin NT, Whitcomb JM, Petropoulos CJ. Bonhoeffer S, et al. Science. 2004 Nov 26;306(5701):1547-50. doi: 10.1126/science.1101786. Science. 2004. PMID: 15567861

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