Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2005 Dec;37(6):509-15.
doi: 10.1007/s10863-005-9500-1.

The intracellular antigen transport machinery TAP in adaptive immunity and virus escape mechanisms

Christian Schölz  1 , Robert Tampé
Affiliations
Review

The intracellular antigen transport machinery TAP in adaptive immunity and virus escape mechanisms

Christian Schölz et al. J Bioenerg Biomembr. 2005 Dec.

Abstract

The transporter associated with antigen processing (TAP) is a crucial element of the adaptive immune system, which translocates proteasomal degradation products into the endoplasmic reticulum, for transfer of these peptides on major histocompatibility complex (MHC) I molecules within a macromolecular peptide-loading complex. After loading and intracellular transport to the cell surface, these peptide/MHC complexes are monitored by cytotoxic T-lymphocytes. This review summarizes the structural organization and function of the ABC transporter TAP. Furthermore, we discuss human diseases and viral evasion strategies associated with TAP function.

PubMed Disclaimer

References

    1. Biol Chem. 2004 Oct;385(10):927-33 - PubMed
    1. Clin Exp Immunol. 2000 Aug;121(2):173-8 - PubMed
    1. Clin Exp Immunol. 2002 Jun;128(3):525-31 - PubMed
    1. Nat Rev Immunol. 2003 Dec;3(12):952-61 - PubMed
    1. Mol Immunol. 2002 Oct;39(3-4):217-33 - PubMed

Publication types

MeSH terms

Substances

LinkOut - more resources