Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1967 Aug;46(8):1356-63.
doi: 10.1172/JCI105628.

Variation of proliferative activity in leukemic cell populations of patients with acute leukemia

E F Saunders  1 , B C Lampkin, A M Mauer
Affiliations

Variation of proliferative activity in leukemic cell populations of patients with acute leukemia

E F Saunders et al. J Clin Invest. 1967 Aug.

Abstract

In 31 children with acute leukemia, the proliferative activity of the leukemic marrow cell population as measured by mitotic and labeling indexes varied widely from patient to patient and from one disease stage to another. Leukemic marrow had a small but statistically significant diurnal variation of proliferative activity. Changes in labeling indexes were directly related to changes in the proportion of large dividing blasts in the marrow. Generation times of dividing leukemic blast cells in 3 patients were similar at diagnosis and in relapse. Changes in proliferative activity of leukemic marrow can be explained by progressive accumulation of nondividing leukemic cells.

PubMed Disclaimer

References

    1. Blood. 1965 Jul;26:1-7 - PubMed
    1. J Lab Clin Med. 1965 Sep;66(3):483-92 - PubMed
    1. Medicine (Baltimore). 1962 Sep;41:163-225 - PubMed
    1. Arch Pathol. 1963 Feb;75:156-61 - PubMed
    1. Acta Med Scand. 1965 Sep;178(3):263-80 - PubMed