Review
doi: 10.1016/j.tips.2006.04.007.
Epub 2006 May 11.
Emerging cancer therapeutic opportunities target DNA-repair systems
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- PMID: 16697054
- DOI: 10.1016/j.tips.2006.04.007
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Review
Emerging cancer therapeutic opportunities target DNA-repair systems
Trends Pharmacol Sci.
2006 Jun.
Abstract
DNA-damaging agents have a central role in non-surgical cancer treatment. The balance between DNA damage and repair determines the final therapeutic consequences. An elevated DNA-repair capacity in tumor cells leads to drug or radiation resistance and severely limits the efficacy of these agents. Interference with DNA repair has emerged as an important approach in combination therapy against cancer. Anticancer targets in DNA-repair systems have emerged, against which several small-molecule compounds are currently undergoing clinical trials.
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