Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Jul 15;16(14):3713-8.
doi: 10.1016/j.bmcl.2006.04.068. Epub 2006 May 11.

Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents

Roland W Bürli  1 , Han Xu, Xiaoming Zou, Kristine Muller, Jennifer Golden, Mike Frohn, Matthew Adlam, Matthew H Plant, Min Wong, Michele McElvain, Kelly Regal, Vellarkad N Viswanadhan, Philip Tagari, Randall Hungate
Affiliations

Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents

Roland W Bürli et al. Bioorg Med Chem Lett. .

Abstract

We report the discovery of potent agonists for the human formyl-peptide-like 1 receptor (hFPRL1). These compounds did not act at a closely related receptor denoted human formyl peptide receptor (hFPR) up to 10 microM concentration. Recent studies have indicated that agonizing this receptor may promote resolution of inflammation. In an exploratory study, a novel hFPRL1 agonist showed efficacy in a mouse ear inflammation model following oral administration.

PubMed Disclaimer

LinkOut - more resources