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Comment
. 2006 May;9(5):331-2.
doi: 10.1016/j.ccr.2006.05.003.

Ewing's sarcoma: general insights from a rare model

Sean Davis  1 , Paul S Meltzer
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Ewing's sarcoma: general insights from a rare model

Sean Davis et al. Cancer Cell. 2006 May.
Free article

Abstract

Ewing's sarcoma is characterized by the presence of fusion oncoproteins involving EWSR1 and an ETS gene, most commonly FLI1. In this issue of Cancer Cell, Smith et al. have combined RNA interference with expression profiling to study the pattern of gene expression downstream of the most common of these fusions, EWS/FLI. Using this strategy, Smith et al. have identified a homeobox gene, NKX2.2, which is both highly expressed in Ewing's sarcoma and essential for the transforming activity of EWS/FLI.

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