Review
doi: 10.1016/j.semcancer.2006.03.008.
Epub 2006 Apr 1.
Epigenetic silencing of 14-3-3sigma in cancer
Affiliations
- PMID: 16698281
- DOI: 10.1016/j.semcancer.2006.03.008
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Review
Epigenetic silencing of 14-3-3sigma in cancer
Semin Cancer Biol.
2006 Jun.
Abstract
The 14-3-3sigma gene is a direct target of the p53 tumor suppressor and its product inhibits cell cycle progression. Recently, a proteomic analysis revealed that 14-3-3sigma regulates additional cellular processes relevant to carcinogenesis, as migration and MAP-kinase signalling. The expression of 14-3-3sigma is down-regulated by CpG methylation in several types of human cancer, among them prostate, lung, breast and several types of skin cancer. The epigenetic inactivation of 14-3-3sigma occurs at an early stage of tumor development and may allow evasion from senescence and promote genomic instability. In the future the detection of CpG methylation of 14-3-3sigma may be used for diagnostic and prognostic purposes.
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