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Review
. 2006 Jun;92(6):855-61.
doi: 10.1136/hrt.2005.060202.

The genetics of heart attack

Eric J Topol  1
Affiliations
Review

The genetics of heart attack

Eric J Topol. Heart. 2006 Jun.
No abstract available

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Conflict of interest statement

In compliance with EBAC/EACCME guidelines, all authors participating in Education in Heart have disclosed potential conflicts of interest that might cause a bias in the article

References

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    1. McCarthy J J, Parker A, Moliterno D J.et al for the GENEQUEST Investigators. Large‐scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes. J Med Genet 200441334–341.First high‐throughput study of variants for myocardial infarction which would now be considered of limited scope. - PMC - PubMed
    1. Yamada Y, Izawa H, Ichihara S.et al Prediction of the risk of myocardial infarction from polymorphisms in candidate genes. N Engl J Med 20023471916–1923.Extensive genotyping of patients with sporadic myocardial infarction demonstrating four gender‐specific variants that were statistically significant. - PubMed
    1. Shiffman D, Ellis S G, Rowland C M.et al Identification of four gene variants associated with myocardial infarction. Am J Human Genet 200577596–605.Recent whole genome SNP study of 6891 genes identifying four variants associated with myocardial infarction. - PMC - PubMed
    1. Wang Q, Rao S, Shen G ‐ Q.et al Premature myocardial infarction novel susceptibility locus on chromosome 1p34–36 identified by genome‐wide linkage analysis. Am J Human Genet 200474262–271.The GeneQuest genome wide linkage study that demonstrated a very substantial chromosome linkage peak for myocardial infarction. - PMC - PubMed

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