Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2006 Jun;13(6):555-6.
doi: 10.1038/nsmb1096. Epub 2006 May 14.

The structure of the exocyst subunit Sec6p defines a conserved architecture with diverse roles

Mylavarapu V S Sivaram  1 , Melonnie L M Furgason, Daniel N Brewer, Mary Munson
Affiliations

The structure of the exocyst subunit Sec6p defines a conserved architecture with diverse roles

Mylavarapu V S Sivaram et al. Nat Struct Mol Biol. 2006 Jun.

Abstract

The exocyst is a conserved protein complex essential for trafficking secretory vesicles to the plasma membrane. The structure of the C-terminal domain of the exocyst subunit Sec6p reveals multiple helical bundles, which are structurally and topologically similar to Exo70p and the C-terminal domains of Exo84p and Sec15, despite <10% sequence identity. The helical bundles appear to be evolutionarily related molecular scaffolds that have diverged to create functionally distinct exocyst proteins.

PubMed Disclaimer

Publication types

Substances

Associated data