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. 2006 May 15:2:12.
doi: 10.1186/1746-160X-2-12.

Gene-enhanced tissue engineering for dental hard tissue regeneration: (1) overview and practical considerations

Paul C Edwards  1 , James M Mason
Affiliations

Gene-enhanced tissue engineering for dental hard tissue regeneration: (1) overview and practical considerations

Paul C Edwards et al. Head Face Med. .

Abstract

Gene-based therapies for tissue regeneration involve delivering a specific gene to a target tissue with the goal of changing the phenotype or protein expression profile of the recipient cell; the ultimate goal being to form specific tissues required for regeneration. One of the principal advantages of this approach is that it provides for a sustained delivery of physiologic levels of the growth factor of interest.This manuscript will review the principals of gene-enhanced tissue engineering and the techniques of introducing DNA into cells. Part 2 will review recent advances in gene-based therapies for dental hard tissue regeneration, specifically as it pertains to dentin regeneration/pulp capping and periodontal regeneration.

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